WebGBR 1342 is a bispecific monoclonal antibody that targets CD3 on T cells and CD38 on myeloma cells where it has demonstrated the ability to direct T cells cytotoxicity towards myeloma cells. 50 Based on the results of these preclinical studies, GBR 1342 is currently being investigated as monotherapy in highly pretreated relapsed/refractory … WebNational Center for Biotechnology Information
2024 ASCO Multiple Myeloma Abstracts - Journal of Clinical …
WebJul 9, 2024 · Bispecific Antibodies: A New Era of Treatment for Multiple Myeloma J Clin Med. 2024 Jul 9;9 (7):2166. doi: 10.3390/jcm9072166. Authors Xiang Zhou 1 , Hermann Einsele 1 , Sophia Danhof 1 Affiliation 1 Department of internal medicine II, University Hospital Würzburg, Oberdürrbacher Street 6, D-97080 Würzburg, Germany. PMID: … WebOct 1, 2024 · Talquetamab, a GPRC5D x CD3 bispecific antibody, has been granted a breakthrough therapy designation and an orphan drug designation from the FDA as a treatment for adult patients with relapsed/refractory multiple myeloma who have received at least 4 prior lines of therapy, including with a proteasome inhibitor, an … nova nexus building
Cancers Free Full-Text Current Main Topics in Multiple Myeloma
WebMar 17, 2024 · Bispecific Antibodies Promise to be ‘Transformative’ in Multiple Myeloma. Mar 17, 2024. Nicholas Wrigley. A panel of experts reviews how the recent approval of … WebThe 2024 ASCO Annual Meeting Proceedings – Multiple Myeloma Abstracts Edition is a listing of all accepted abstracts from the multiple myeloma track of the 2024 ASCO Annual Meeting. Phase II study of umbilical cord blood–derived natural killer (CB-NK) cells with elotuzumab, lenalidomide, and high-dose melphalan followed by autologous stem ... WebJun 14, 2024 · Bispecific antibodies, also known as T-cell engagers or T-cell redirective therapy, are showing great promise in relapsed/refractory myeloma. Bispecific antibodies are antibodies that have two arms. One of the arms is drawn to a target antigen, such as BCMA or GPRC5D, which is located on the myeloma cell. nova night creatures of the kalahari