WebJan 24, 2024 · Chitosan has attracted attention in various biomedical, pharmaceutical, food, and environmental fields due to its safe profile, biodegradability, and biocompatibility, in addition to its bacteriostatic and mucoadhesive properties ( Alves and Mano, 2008; Riva et al., 2011; Miola et al., 2015; Silva et al., 2024; Bracharz et al., 2024; Dmour and … WebChitosan, a cationic polymer, is widely used for its biodegradable and biocompatible properties and it undergoes electrostatic interactions with the negatively charged mucin chains thereby exhibiting mucoadhesive property (Portero et al. Citation 2007). The ionic polymers may be used to develop ionic complex with the counter-ionic drug ...
Why is Chitosan Mucoadhesive? Biomacromolecules
WebChitosan, the second naturally abundant polysaccharide is a biocompatible, biodegradable and mucoadhesive cationic polymer which has been exploited extensively in the last few years in the effective delivery of anticancer chemotherapeutics to the target tumor cells. Therapeutic agent-loaded surface modified chitosan nanoparticles are ... WebFeb 1, 2024 · Maleimide-bearing chitosan (Mal-CS) and catechol-bearing alginate (Cat-Alg) were synthesized to develop mucoadhesive NPs with dual mucoadhesive moieties (Mal-CS-Cat-Alg). The NPs had a size of 116 ... simple gui for worldbox
Oral Deliverable Mucoadhesive Chitosan- Salmonella Subunit …
WebJan 25, 2024 · The aim of this study was to develop prednisolone containing child-friendly chitosan-based mucoadhesive films and wafers with a prolonged residence time on the buccal mucosa. Four different chitosan types (different molecular weights, degree of deacetylation (DDA), pattern of deacetylation) were studied for films prepared by solvent … WebFeb 18, 2010 · Chitosan is one of the most promising polymers because of its non-toxic, polycationic biocompatible, biodegradable nature, and particularly due to its mucoadhesive and permeation enhancing properties. Due to its potential importance in controlled drug delivery applications, pharmaceutical scientists have exploited this mucoadhesive polymer. WebDec 1, 2014 · Chitosan is a mucoadhesive polymer with permeation enhancing properties ; it facilitates the opening of epithelial tight junctions , which prevent sialic acid from eroding mucosa. This may attributed to the electrostatic attraction between its positively charged d -glucose-amine residues and the negatively charged sialic acid residues of mucin. simple gryffindor crest