Cisplatin chemistry

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August undefined, 2024

WebCisplatin coordinates to DNA mainly through certain nitrogen atoms of the DNA base pairs; these nitrogen atoms (specifically, the N7 atoms of purines) are free to coordinate to cisplatin because they do not form hydrogen bonds with any other … WebThe microstructure and properties of metal ion-assisted cisplatin-loading SLNs were investigated by infra-red spectroscopy, fluorescence spectroscopy and zetasizer. The reactions of hydrogenated soybean lecithin with Zn(2+), Cu(2+), Mn(2+ )and Mg(2+ )have been detected; the mechanism for higher drug encapsulation efficiency (EE) has been ...

Cisplatin - Wikipedia

WebJan 28, 2024 · In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products. WebConspectusSince its discovery in 1965, the inorganic drug cisplatin has become a mainstay of cancer therapies and has inspired many platinum (Pt)-based compounds to solve … daily recommended potassium intake canada

Cisplatin Podcast Chemistry World

WebThis book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how … WebCisplatin / chemistry Cisplatin / metabolism* Colonic Neoplasms / metabolism* Colonic Neoplasms / pathology Copper / metabolism Copper / pharmacokinetics Copper Transporter 1 Dose-Response Relationship, Drug Homeostasis Humans Platinum / metabolism Platinum / pharmacokinetics Structure-Activity Relationship Substances Cation Transport Proteins WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … bio means in facebook

Cisplatin 9. The Discovery - Chemistry LibreTexts

WebCisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug Wiley 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most … WebThe antitumor effects of platinum(IV) complexes, considered prodrugs for cisplatin, are believed to be due to biological reduction of Pt(IV) to Pt(II), with the reduction products binding to DNA and other cellular targets. In this work we used pBR322 DNA to capture the products of reduction of oxopl … Pt(IV) complexes as prodrugs for cisplatin bio meaning in cyberbackerWebIn water, the antineoplastic drug cisplatin, cis- [PtCl2 (NH3)2] (1) hydrolyses slowly to the aqua complexes cis- [Pt (NH3)2Cl (H2O)]+ (2) and, to a small extent, cis- [Pt (NH3)2 (H2O)2]2+ (3), which are thought to play an important role in the metabolism of cisplatin. daily recommended maximum salt intake

"WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … " - Cisplatin chemistry

Cisplatin chemistry

Cancer Drug 49 Times More Potent than Cisplatin

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … WebApr 9, 1999 · 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce …

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WebCisplatin: chemistry, distribution and biotransformation Authors D F Long , A J Repta PMID: 7016212 DOI: 10.1002/bdd.2510020102 Abstract A review of the use of cisplatin … WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, …

WebHypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two strategies for the modulation of HICR against … WebJun 10, 1999 · Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry …

WebIn the 1960s the drug cis-platin was discovered, which has been extremely effective in treating a number of different types cancer such as testicular, ovarian, cervical, breast, lung and brain cancer. Cancer cells grow and replicate much faster than normal cells. Cis-platin is a square planar molecule that has a geometric isomer with the side ... Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl…

WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … daily recommended sodium for men daily recommended protein per dayWebCisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. … bi/o meaning medicalWebNov 4, 2013 · Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor … daily recommended nutrition intake calculatorWebSep 30, 2024 · Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair. daily recommended sodium intake for menWebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … daily recommended trans fatWebOct 5, 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° … biomeasures